Identification of various factors associated with in-vitro fertilization treatment in infertility cases

Abstract

Infertility is a worldwide problem affecting people of all communities. It is estimated that globally 60-80 million couples suffer from infertility every year of which between 15-20 million are in India alone. Infertility affects every eighth couple during reproductive life by reducing fertility rates due to various factors and excessive stress of fast moving work life, resulting in imbalanced hormone stimulation and diseases related to reproductive organs. These factor works as a barrier to the couples for a successful conception. In-vitro fertilization and Intracytoplasmic sperm injection are the most accepted treatment and frequent choice to overcome the infertility problem. The present study focuses on various factors affecting fertility in couples and possibilities of live birth through in-vitro fertilization and intracytoplasmic sperm injection treatment. In this study, 200 couples facing infertility problems were included. In-vitro fertilization and Intracytoplasmic sperm injection treatment were received by these couples to increase their chances of pregnancy and live birth. Clinical examination, diagnosis, analysis and procedure of In-vitro fertilization including embryo transfer technique and calculation of live births were carried out by following clinical guidelines of National Institute for Health Care and Excellence (NICE). To evaluate cumulative possibilities of ongoing pregnancy, Kaplan-Meier analysis was done. The highest pregnancy chances were given by oligospermia, however the immunological/cervical pathology gives the lowest chances. The upshots exposed that the chance of a live birth diminishes as the number of unsuccessful cycles raises. The age of women negatively influences the live birth rates and the cleavage transfer were found less successful than blastocyst transfers. The single embryo transfer resulted only 2% to 3% of live birth and double embryo transfer resulting around 32% more multiple live births. In conclusion the study supports the singleton live birth as a primary output. Clinical Pregnancy and singleton live birth are significant results of this study allow gynaecologists to inform the couples for possibilities of conception.