Serum food and beverage levels in patients with Parkinson's disease and their evaluation of white matter lesions

Abstract

Objective To investigate the levels of serum cystatin C (CysC) and homocysteine (Hcy) in patients with Parkinson's disease and their evaluation effects on associated white matter lesions. Methods The data of 124 patients with Parkinson's disease admitted to this hospital from December 2017 to December 2019 (research group) and 115 healthy volunteers (control group) who underwent physical examination in this hospital were retrospectively analyzed. Results The serum CysC and Hcy levels of the study group were (1.37±0.25) mg/L and (0.89±0.14) μmol/L respectively, which were higher than those of the control group (20.54±3.21) mg/L and (14.89±2.18) μmol/L. L, the difference was statistically significant (P<0.05). There were 35 patients in the study group with white matter lesions, and the incidence rate was 28.23%; the serum CysC and Hcy levels of those with white matter lesions in the study group were (1.58±0.29) mg/L and (23.32±3.58) respectively. μmol/L was higher than (1.29±0.22) mg/L and (19.45±3.12) μmol/L of those without white matter lesions, the difference was statistically significant (P<0.05). Age, duration of Parkinson's disease, hypertension, diabetes, serum CysC and Hcy were all risk factors for leukoencephalopathy in the study group (P<0.05). The cut-off values of serum CysC and Hcy levels in assessing white matter lesions associated with Parkinson's disease are 1.25 mg/L and 21.02 μmol/L respectively. The sensitivity and AUC of the two combined to assess white matter lesions associated with Parkinson's disease are 100.00% and 0.953 respectively. , were higher than the evaluation of individual indicators (P<0.05). Conclusion Patients with Parkinson's disease have high serum CysC and Hcy levels, which are associated with a high risk of white matter lesions; serum CysC, Hcy and age, duration of Parkinson's disease, hypertension, diabetes, etc. are all influencing factors; serum CysC, Hcy The combined evaluation of levels of Parkinson's disease with white matter lesions has high efficacy. [International Journal of Neurology and Neurosurgery, 2021, 48(6):511-515