Neurogenic Alterations in the pilocarpine induced epileptic activity of Wistar rats treated with Saraswata Churna

Abstract

Approximately 80% of patients with TLE have temporal lobe epilepsy (TLE), one of the most drug-resistant seizure diseases. One of the most common signs of status epilepticus is memory impairment. Cognitive deficits are more common in patients with temporal lobe epilepsy (TLE). The findings imply that this decline in cognitive performance may be related to the development of localized brain lesions, particularly in the cortical and hippocampus areas. We generated chronic epileptic rats treated with pilocarpine in order to replicate the cognitive impairments linked to epilepsy in an animal model. We provide a protocol for two behavioral tests that are administered to epileptic rats: the Novel Object Recognition Test (NORT) to assess memory for objects, and the Morris Water Maze Test (MWMT) to assess memory for places. The purpose of the current study was to determine if the ayurvedic herb Saraswata Churna (SC) serves as a neuroprotective agent, reducing hippocampus damage and improving learning and memory performance. Using a rat model of pilocarpine-induced epilepsy, the current study examined the therapeutic effects of SC on memory and learning. Four groups were used: a normal control (NC), a pilocarpine (PI) group, a phenytoin (PHE) treated group, and a Saraswata Churna (SC) treated group. In order to investigate the potential therapeutic effects of SC for improving learning and memory, a rat model of TLE was established using lithium-pilocarpine. Our research revealed that focal brain lesions, specifically in the hippocampus and cortical regions in the SE rat model, caused cognitive abnormalities in epilepsy-induced rats. These abnormalities significantly hampered the rats' ability to learn and remember things. Preventive treatment with SC reduced learning and memory deficits by preventing neuronal cell loss and repairing hippocampal cell damage.