Malnutrition And Cerebral Intraparenchymal Damage In Patients With Thrombosis Of Dural Sinuses And /Or Cerebral Veins

Abstract

Introduction: Malnutrition is a complex and multifactorial condition characterized by an imbalance in nutrient intake, absorption, and utilization, leading to adverse effects on physical and cognitive health. Objectives: The main objective of the study is to find the role of malnutrition and cerebral intraparenchymal damage in patients with thrombosis of dural sinuses and cerebral veins. Material and methods: This retrospective observational study was conducted in tertiary care hospital of Hyderabad, Jamshoro and Nawabshah from December 2022 to November 2023. Data were collected from 205 patients. A comprehensive search of electronic medical records was conducted to identify eligible patients diagnosed with thrombosis of dural sinuses and/or cerebral veins (TDS/CV). Relevant demographic information, clinical characteristics, imaging findings, and nutritional status data were extracted from the medical records of eligible patients. Results: Data were collected from 205 patients from both genders. There were 54% male and 46% female patients. Mean age of the patients was 45.01±12.3 years. Imaging findings revealed cerebral intraparenchymal damage in 60% of patients, with ischemic infarction, hemorrhage, and edema observed in 40%, 20%, and 10% of cases, respectively. 35% of patients were classified as malnourished, while 45% were deemed at risk of malnutrition. BMI < 18.5 kg/m² was observed in 25% of patients, indicating undernutrition based on body mass index criteria. Additionally, 40% of participants had a Mid Upper Arm Circumference (MUAC) below the 5th percentile, indicating poor nutritional status based on this anthropometric measurement. Conclusion: It is concluded that malnutrition is highly prevalent among patients with thrombosis of dural sinuses and/or cerebral veins and is significantly associated with cerebral intraparenchymal damage.