Clinico- etiopathological study and outcome of acute enchephalitis syndrome -a hospital based prospective observational study”
Keywords:
Acute encephalitis syndrome; HSV,dengue virus; Japanese encephalitis virus; scrub typhus.Abstract
Background & objectives: Acute encephalitis syndromeis aserious public health problem and mainly caused by viruses. The etiological diagnosis of acute encephalitis syndrome cases is essential for better patient management and policymaking. The present study was carried out to determine the clinicetio-pathological profile and outcome of acute encephalitis syndrome in tertiary center in Bhubaneshwar.
Methods:Serum and/or Cerebrospinal fluid were collected from acute encephalitis syndrome patients admitted at IMS & SUM Hospital, a tertiary care center, Bhubaneswar, Odisha between October 2019-september 2021. Cerebrospinal fluid and serum were tested for bacteriological culture and IgM antibodies against the HSV,Japanese encephalitis virus, dengue virus and scrub typhus by ELISA.
Results: Among the 128 cases 79.2% were suspected for viral etiology out of which HSV (5.88%), Japanese encephalitis (2%). Followed by bacterial (19.5%) out of which scrub typhus (38%), and tubercular meningitis (0.8%) were responsible for acute encephalitis syndrome.
Interpretation & conclusion:HSV, Dengue virus and Japanese encephalitis virus scrub typhus are most common causative etiological agents in our study, they are more prevalent during monsoon and post-monsoon seasons.
