Subacute sclerosing panencephalitis and mechanisms of persistent viral infection

Abstract

1. The process of isolating viruses from subacute sclerosing panencephalitis In 1933, Dawson reported subacute sclerosing panencephalitis (SSPE) using the term "inclusion body encephalitis". At that time, the virus was already considered Possibility, but could not be proved for a long time. In 1965, Bouteille et al. used electron microscopy to find that inclusion bodies in nerve cells were similar to the nucleoprotein shell of measles virus. Connolly et al. (1967) used fluorescent antibody method to prove that inclusion bodies in the brain tissue of patients There is specific fluorescence for measles, and it was also found that the antibody titer in the patient's serum and cerebrospinal fluid was significantly increased