Morphological and Morphometric Changes in the Valves of the Heart in Experimental Toxic Myocarditis
Keywords:
Rat heart, Postnatal ontogenesis, Cardiomyocytes, Fibrous structure atria, and ventricles.Abstract
The present study aims to identify postnatal development's morphogenesis characteristics while examining the rat heart's membranes and various departments' histological structures 1 to 22 days after birth. Fifty rats were chosen as the study's subjects, and the morphological changes in their hearts were observed at 1, 6, 11, 16, and 22 days after birth. Alternating periods of acceleration and deceleration of the growth rate with increasing thickness of atria and ventricles were noted. Pesticide toxicity caused specific pathological morphological changes in rat heart tissue, including nuclear-cytoplasmic ratio violations and myofibril loosening. Protein dystrophy, connective cell proliferation, and disorganization of the fibrous structures in the wall of capillaries and arterioles were also observed in the muscle fibers of the myocardium. Compared to controls, experimental animals' atrial wall layers, and ventricles exhibit a significant decrease in morphometric parameters. The myocardium underwent changes resembling necrosis in the latter stages of the experiment.
