Parkinson's Disease: Neurodegeneration and the Potential Role of Medicinal Plants

Abstract

Parkinson's disease (PD) is a developing neurodegenerative disease that occurs due to dopamine neurodegeneration occurring through various factors. Progressive loss of dopaminergic (DA-ergic) neurons in the Substantia Nigra pars compacta (SNpc) region of the brain is the defining feature of PD, though the cause of the condition is still unknown. The main causes are thought to be mitochondrial dysfunction and oxidative stress. Levodopa is the leading component of the current PD treatment, which has a lot of side effects but has the potential to somewhat slow the progression of the disease. Medicinal plant-based therapy is an effective approach to critically prevent neurodegeneration disease for long-term symptoms. The following review's objective is to describe some of the important medical natural plants, such as Curcuma Longa, Gingko Biloba, Bacopa Monnieri, Withania somnifera, Ocimum Santam, Panax Ginseng, Polygonum Cuspidatum, Mucuna Pruriens, Sida cordifolia, Carthamus Tinctorius, Hibiscus Asper, Tinospora Cordifolia, Polygala tenuifolia, Paeonia lactiflora and Camellia Sinensis (Green tea)) in light of their potential for neuroprotection as well as in the creation of new treatment plans for PD.