Effects of internal diameter and microsurgical treatment on postoperative serum MMP-9 IGF-1, hormone-related index levels, in patients with pituitary adenoma

Abstract

Objective To investigate the effect of endoscopic and microsurgery on serum matrix metalloproteinase-9 (MMP-9), insulin-like growth factor-1 (IGF-1) and hormone-related indexes in patients with pituitary adenoma after operation. Methods A total of 96 patients with pituitary adenoma admitted to the neurosurgery department of Handan Central Hospital from January 2017 to January 2020 were divided into endoscopic group (tumor resection under neuroendoscopy) and microscopic group (neuroendoscopic tumor resection) and microscope group (microscopic examination) by random numerical table method. tumor resection). The surgical indicators and postoperative complications of the two groups were recorded; serum MMP-9, IGF-1, prolactin (PRL), growth hormone (GH) and adrenocorticotropic hormone (ACTH) were detected before operation and on the third day after operation level. Results Compared with the microscope group, the endoscopic group had longer operation time and better tumor resection, and the difference was statistically significant (P<0.05). The serum MMP-9, IGF-1, PRL, GH and ACTH levels in the postoperative endoscopic group were lower than those in the endoscopic group, and the differences were statistically significant (P<0.05). The total incidence rates of postoperative complications in the endoscopic group and microscopy group were 10.42% and 27.08%, respectively, with no statistically significant difference (P>0.05). Conclusion Neuroendoscopic operation time is longer than that of microscope, but it has more advantages in removing tumors and reducing postoperative serum MMP-9, IGF-1 and hormone index levels. [International Journal of Neurology Neurosurgery, 2021, 48(6):538-541.]