SEDATION AND ANALGESIC REQUIREMENT AND THEIR EFFECT ON COMA, AND MORTALITY IN ICU MECHANICALLY VENTILATED PATIENTS WITH COVID VS NON-COVID PATIENTS

Authors

  • Qasem Ali Bahri 1*, Marwa Amer 2, Rayd A. Al-mehizia 3, Qoot Almedainy 4, Meshari Alghamdi 5, Ahmed Yahya Haqawi 6*, Fahad Mohammed Harshan 7, Sultan Ibrahim Shaiban 8, Mohammed Abdu Ahmed Tawhari 9, Mohammed Abdullah Noshily 10, Majed Hassan Mathkur 11 a Author

Keywords:

Participants will be recruited from KFSH&RC, a major referral center that provides tertiary and quaternary care.

Abstract

BACKGROUND

Sedatives and opioids are often used in patients with coronavirus disease 2019–associated acute respiratory distress syndrome, which may enhance their vulnerability to neurologic dysfunction. We tested the hypothesis that patients with coronavirus disease 2019–associated acute respiratory distress syndrome are at higher risk of in-hospital mortality due to prolonged coma compared with other patients with acute respiratory distress syndrome matched for disease severity.

OBJECTIVES:

To study the effect of sedation on mortality and coma-free days in COVID-19 patients admitted to the ICU compared to non – COVID – 19 ICU patients. Also, to investigate the possible causes of coma in ICU patients

DESIGN: Retrospective cohort study using propensity matching score

SETTING: Participants will be recruited from KFSH&RC, a major referral center that provides tertiary and quaternary care.

Intervention: None

Primary endpoint:

  • difference in cumulative analgesia and sedation dose 48 hours after ICU admission of patients with non-COVID (ATTAINMENT pilot study cohort) compared to patients with COVID-19. We will compare the groups for differences in types of agents utilized, doses (both average and cumulative) and duration

Secondary endpoint:

We will look also at in – hospital mortality, the percentage of comatose days and the causes of coma in ICU patients.

Downloads

Published

2024-12-30

Issue

Vol. 28 No. 3 (2024)

Section

Articles